Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Li Di, Edward H Kerns

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ISBN: 9780128010761 | 580 pages | 15 Mb

• Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
• Li Di, Edward H Kerns
• Page: 580
• Format: pdf, ePub, fb2, mobi
• ISBN: 9780128010761
• Publisher: Elsevier Science

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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

Drug-like Properties: Concepts, Structure Design and Methods
The online version of Drug-like Properties: Concepts, Structure Design and Methods by Edward H. Kerns and Li Di on from ADME to Toxicity Optimization. Teaching | Hao Zhu | Rutgers University
Required Textbook: Drug-like Properties: Concepts, Structure Design and Methods-from ADME to Toxicity Optimization by Kerns and Di, ISBN  Trekking Through Receptor Chemistry - Università di Camerino
Integration of drug-like properties in selection, optimization and biological As part of our effort to develop novel concepts in schizophrenia therapy, we Structure Design and Methods: from ADME to Toxicity Optimization,. Drug-like Properties: Concepts, Structure Design and Methods: from
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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity engaged in, or preparing for, the selection and optimization process. Pharmacokinetics, Metabolism, and in Vivo Efficacy of the
Lead optimization requires identification of biochemical and The lack of mouse toxicity (in either the PK study or the in vivo efficacy study) [PubMed]; Kerns E.; Di L.Drug-Like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization; Academic Press: New York, 2008. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for
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For drug candidates, a plasma protein binding (PPB) more than 90% is more meaningful and [7] E. H. Kerns and L. Di, Drug-Like Properties: Concepts, Structure. Design and Methods: From ADME to Toxicity Optimization,. Drug-like properties : concepts, structure design and methods
Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization. By Edward Harvel Kerns; Li Di. Print book. 영어. 2008. Drug-Like Properties Concepts, Structure Design and Methods
Drug-Like Properties Concepts, Structure Design and Methods - From ADME to Toxicity Optimization. Book in english language. Di, Li. Prodrug ADME Services - Cyprotex
3 Kerns EH and Di L (2008) Drug-like properties: concepts, structure design and methods – from ADME to toxicity optimization Ed. Kerns and Di; 426-438. Concepts, Structure Design and Methods: from ADME to Toxicity
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